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Native valve Aspergillus endocarditis complicating lung transplantation

Toby M Maher1, Martin R Carby, Anne V Hall

  • 1Cardiothoracic Transplant Unit, Harefield Hospital, Harefield, Middlesex, UK. t.maher@ucl.ac.uk

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|July 29, 2008
PubMed

Insights

Aspergillus endocarditis is a serious complication in lung transplant patients. Early treatment with surgery and antifungals is crucial, but the disease can recur, requiring ongoing therapy.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Transplant Surgery

Background:

  • Aspergillus endocarditis is a rare but severe infection affecting heart valves.
  • Lung transplant recipients are immunocompromised, increasing susceptibility to opportunistic infections like aspergillosis.

Observation:

  • Two lung transplant recipients developed Aspergillus endocarditis without prior airway colonization.
  • Hematogenous spread during surgery is a potential infection route.

Findings:

  • Both patients received early surgical intervention and triazole antifungal therapy.
  • One patient experienced a fatal recurrence 10 months post-discharge despite initial recovery.

Implications:

  • Aspergillus endocarditis should be recognized as a potentially relapsing condition.
  • Long-term antifungal therapy is recommended for survivors of Aspergillus endocarditis.

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