Related Experiment Video
Updated: Feb 6, 2026
08:58
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
8.0K
Aspirin resistance: disparities and clinical implications
Anita Airee1, Heather M Draper, Shannon W Finks
1University of Tennessee College of Pharmacy, Knoxville Campus, 1924 Alcoa Highway, Knoxville, TN 37920, USA. aairee@utmem.edu
Pharmacotherapy
|July 29, 2008
Summary
Aspirin resistance, the failure of aspirin to prevent thrombosis, affects various patient groups and is linked to increased adverse events. A clinical consensus on managing aspirin resistance is still needed.
Area of Science:
- Cardiology
- Pharmacology
- Vascular Medicine
Background:
- Aspirin is a cornerstone therapy for preventing thrombosis in vascular disease.
- However, aspirin fails to prevent thrombotic events in a subset of patients, termed 'aspirin resistance'.
- This resistance has significant clinical implications due to widespread aspirin use for primary and secondary prevention.
Purpose of the Study:
- To broadly define aspirin resistance and explore its underlying causes.
- To investigate the clinical implications and disparities in aspirin resistance across different patient populations and conditions.
- To review evidence associating aspirin resistance with adverse events and highlight the lack of clinical consensus.
Main Methods:
- Literature review of clinical trial data and studies on aspirin resistance.
- Analysis of factors influencing aspirin efficacy, including biochemical resistance and disease-related thrombogenicity.
- Examination of disparities in resistance rates among specific demographics and clinical conditions.
Main Results:
- Aspirin resistance is observed in various patient populations, including women, individuals with diabetes mellitus, and heart failure.
- Increased rates of aspirin resistance are noted in cardiovascular and cerebrovascular diseases.
- Studies consistently show aspirin resistance is associated with a higher risk of adverse events, irrespective of study design or measurement methods.
Conclusions:
- Aspirin resistance is a significant clinical concern with demonstrable links to adverse thrombotic events.
- Disparities in aspirin resistance exist across diverse patient groups and clinical contexts.
- There is an urgent need for a consensus on the clinical management of patients exhibiting aspirin resistance.
More Related Videos
13:38Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
12.7K
08:46Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
11.2K
Related Concept Videos
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
01:16Equivalent Resistance
987
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
987
01:25Resistance and Conductance
517
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
517
01:21Rolling Resistance
667
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
667
01:20Vascular Resistance
11.1K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.1K