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Association between cerebral microbleeds and prior primary intracerebral hemorrhage in ischemic stroke patients

Ying-Fa Chen1, Yung-Yee Chang, Jia-Shou Liu

  • 1Department of Neurology, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niao-Sung, Kaohsiung County 833, Taiwan.

Clinical Neurology and Neurosurgery
|July 29, 2008
PubMed
Abstract

Insights

Cerebral microbleeds (CMB) on MRI are linked to prior intracerebral hemorrhage (ICH) in stroke patients. CMB in the basal ganglia or thalamus specifically correlates with ICH in those same brain regions.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Cerebral microbleeds (CMB) and intracerebral hemorrhage (ICH) are common findings in patients with ischemic stroke.
  • Understanding the relationship between CMB and prior ICH is crucial for stroke risk assessment and management.

Purpose of the Study:

  • To investigate the association between cerebral microbleeds (CMB) and prior intracerebral hemorrhage (ICH) detected via MRI.
  • To explore the topographic correlation between CMB and ICH lesions in patients with ischemic stroke.

Main Methods:

  • Two hundred and sixty ischemic stroke patients underwent T2-gradient-echo MRI to assess for CMB and prior ICH.
  • Statistical analysis examined the presence and number of CMB as predictors of prior ICH.
  • Topographic correlations between CMB and ICH were tested in specific brain regions (infratentorial, basal ganglionic/thalamic, cortico-subcortical).

Main Results:

  • CMB were detected in 43.5% of patients; prior ICH was found in 15.0%.
  • The presence (OR 2.53) and number (OR 1.11) of CMB were independent predictors of prior ICH.
  • A significant topographic correlation between CMB and ICH was observed in the basal ganglionic/thalamic region (p=0.017).

Conclusions:

  • Cerebral microbleeds (CMB) are significantly associated with prior intracerebral hemorrhage (ICH) in ischemic stroke patients.
  • The location of CMB, particularly in the basal ganglia or thalamus, correlates with the location of prior ICH in the same region.

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