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Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

Christopher A McDevitt1, Chitra A Shintre, J Günter Grossmann

  • 1Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

FEBS Letters
|July 29, 2008
PubMed

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ABC Transporters: Importer01:27

ABC Transporters: Importer

ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types: