Related Experiment Video
Updated: Jul 3, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
Published on: July 4, 2018
Mast cell activation by myelin through scavenger receptor
Nevenka Medic1, Francesca Vita, Rita Abbate
1Department of Physiology and Pathology, University of Trieste, via A. Fleming 22, 34127 Trieste Italy.
Abstract:
A role for mast cells (MC) in the pathogenesis of multiple sclerosis (MS) has been suggested, based on the analysis of human lesions and on an animal model of the disease (EAE). What role MC play in the development of MS is not well understood. We hypothesized that the link connecting MC with demyelinating diseases may be represented by their interaction with myelin. Here we show that myelin can activate mast cells. This process could be a key event in the mast cell function required for inducing EAE in mice and possibly in MS in man.
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