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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...

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Related Experiment Video

Updated: Jul 3, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Age-related muscle dysfunction.

LaDora V Thompson1

  • 1Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S.E., Minneapolis, MN 55455, USA. thomp067@umn.edu

Experimental Gerontology
|July 29, 2008
PubMed
Summary
This summary is machine-generated.

Aging causes muscle loss and weakness, known as sarcopenia. This review explores the cellular and molecular changes behind age-related muscle decline and dysfunction.

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Related Experiment Videos

Last Updated: Jul 3, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

  • Gerontology
  • Muscle Physiology
  • Molecular Biology

Background:

  • Aging leads to a significant decrease in skeletal muscle mass, strength, and quality.
  • This age-related muscle loss is termed sarcopenia of aging.
  • The precise mechanisms driving muscle performance deterioration remain incompletely understood.

Purpose of the Study:

  • To review the cellular, molecular, and biochemical alterations contributing to age-related muscle dysfunction.
  • To provide insights into the complex biological processes underlying sarcopenia.
  • To highlight key factors affecting muscle health during the aging process.

Main Methods:

  • Literature review of existing research on aging and skeletal muscle.
  • Analysis of cellular, molecular, and biochemical changes associated with muscle aging.
  • Synthesis of current knowledge on the mechanisms of sarcopenia.

Main Results:

  • Identified key cellular changes including mitochondrial dysfunction and impaired protein synthesis.
  • Highlighted molecular alterations such as changes in gene expression and signaling pathways.
  • Discussed biochemical shifts involving oxidative stress and inflammation.

Conclusions:

  • Age-related muscle dysfunction is multifactorial, involving complex cellular, molecular, and biochemical changes.
  • Understanding these mechanisms is crucial for developing interventions against sarcopenia.
  • Further research is needed to fully elucidate and target these pathways for improved muscle health in aging individuals.