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Related Concept Videos

Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Cell Culture01:21

Cell Culture

Most vertebrate cells grow in vitro attached to a substrate as a monolayer, called adherent cultures. The flasks and plates used to grow cells are chemically treated to facilitate cell attachment. However, a few cell types, such as hematopoietic cells, can grow in a suspension. In contrast to adherent cultures, suspension cultures can grow in non-treated cultureware using magnetic stirrers or spinner flasks to agitate the culture media
Microbial Classification System01:24

Microbial Classification System

Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array
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Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

The CellML Model Repository.

Catherine M Lloyd1, James R Lawson, Peter J Hunter

  • 1Auckland Bioengineering Institute, The University of Auckland, Auckland 1010, New Zealand. c.lloyd@auckland.ac.nz

Bioinformatics (Oxford, England)
|July 29, 2008
PubMed
Summary
This summary is machine-generated.

The CellML Model Repository offers over 330 free biological models from peer-reviewed studies. Ongoing curation and annotation are vital for ensuring model accuracy and improving data retrieval as the community expands.

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Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array
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Published on: September 7, 2018

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Area of Science:

  • Computational Biology
  • Systems Biology
  • Bioinformatics

Background:

  • The CellML Model Repository is a publicly accessible platform.
  • It houses a substantial collection of biological models.

Purpose of the Study:

  • To highlight the resources available in the CellML Model Repository.
  • To emphasize the importance of model curation and annotation for the scientific community.

Main Methods:

  • Repository access is provided via http://www.cellml.org/models.
  • Models are curated to ensure accurate reproduction of published results.

Main Results:

  • The repository contains over 330 biological models.
  • The majority of models are derived from published, peer-reviewed literature.

Conclusions:

  • Model curation is crucial for maintaining the integrity and reproducibility of biological models.
  • Enhanced model annotation is essential for efficient data searching and retrieval within the growing CellML community.