Related Experiment Videos
MRI reveals multiple reversible cerebral lesions in an attack of acute intermittent porphyria
1Division of Neurology, Duke University Medical Center, Durham, NC.
Neurology
|August 1, 1991
Abstract:
A 20-year-old woman had an attack of acute intermittent porphyria (AIP) with seizures and hallucinations. MRI revealed multiple lesions in both hemispheres. Both the cerebral clinical abnormalities and the MRI lesions resolved following treatment. These findings suggest that a vascular mechanism may underlie the pathogenesis of cerebral dysfunction in AIP.
Insights
Acute intermittent porphyria (AIP) can cause seizures and hallucinations. Brain lesions seen on MRI scans in a patient with AIP resolved after treatment, suggesting vascular issues may cause neurological problems in AIP.
Area of Science:
- Neurology
- Neuroscience
- Genetics
Background:
- Acute intermittent porphyria (AIP) is a rare genetic disorder affecting the heme biosynthesis pathway.
- Neurological complications, including seizures and hallucinations, can occur during AIP attacks.
- The exact mechanisms underlying cerebral dysfunction in AIP remain incompletely understood.