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Clinical correlation with serum-soluble interleukin-2 receptor levels in Guillain-Barré syndrome
S Bansil1, F A Mithen, S D Cook
1Department of Neurosciences, University of Medicine & Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
Neurology
|August 1, 1991
Abstract:
In patients with Guillain-Barré syndrome (GBS) soluble interleukin-2 receptor (sIL-2R) levels were elevated compared with those of patients with other neurologic diseases (OND), and of healthy controls. Smaller increases in sIL-2R levels occurred in OND patients compared to healthy subjects. Monitoring of GBS patients clearly demonstrated that decreases in sIL-2R levels correlated with clinical recovery. Thus, T-cell activation may be relevant in the pathogenesis of GBS.