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Related Experiment Video

Updated: Jul 3, 2026

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

The future of high-throughput screening.

Lorenz M Mayr¹, Peter Fuerst

¹Novartis Institutes of BioMedical Research, Center of Proteomic Chemistry, Basel, Switzerland. Lorenz.Mayr@novartis.com

Journal of Biomolecular Screening

|July 29, 2008

Summary

This summary is machine-generated.

High-throughput screening (HTS) has evolved from increasing capacity to prioritizing data quality in drug discovery. Future HTS strategies will become more tailored and integrated into broader research efforts.

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Area of Science:

Biomedical Research
Drug Discovery
Pharmacology

Background:

High-throughput screening (HTS) is a critical process in pharmaceutical and biotech lead discovery.
HTS has matured significantly since the 1990s, adapting to evolving research needs.
The field is increasingly adopted by academic institutions and research hospitals.

Observation:

Historically, HTS focused on increasing throughput via automation and miniaturization.
Recent years show a shift towards enhancing the content and quality of biological test systems.
Experts perceive HTS at a critical juncture, balancing throughput increases with biological data relevance.

Findings:

The trend of further miniaturization in HTS is predicted to decelerate with the adoption of 384-well and 1536-well plates.
Future HTS approaches will likely involve a move away from a one-size-fits-all strategy.
The development of HTS over the past decade highlights a move towards quality over quantity.

Implications:

HTS strategies will become more project-specific, customized, and integrated into overall drug discovery pipelines.
This shift suggests a move towards more efficient and relevant drug discovery processes.
Academic and clinical research settings will benefit from more refined HTS methodologies.