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Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Updated: Jul 3, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Prostate cancer in elderly men.

Anton Stangelberger, Matthias Waldert, Bob Djavan

    Reviews in Urology
    |July 29, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Elderly men diagnosed with prostate cancer may benefit from radical prostatectomy, a potentially curative treatment. Expectant management is an option for low-grade disease, reserving active treatment for progression.

    Keywords:
    Elderly menOvertreatmentProstate cancerProstate-specific antigenQuality of lifeScreening

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    A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
    05:19

    A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

    Published on: November 7, 2025

    Area of Science:

    • Urology
    • Oncology
    • Geriatrics

    Background:

    • Increasing life expectancy and prostate-specific antigen (PSA) screening lead to more elderly men diagnosed with prostate cancer.
    • Age is a critical prognostic factor influencing treatment decisions for prostate cancer.
    • Overdiagnosis of prostate cancer is a concern due to widespread PSA screening.

    Purpose of the Study:

    • To evaluate the role of radical prostatectomy in elderly men with organ-confined prostate cancer.
    • To discuss the concept of expectant management for screen-detected, low-grade prostate cancer.
    • To inform treatment decisions considering patient age and disease characteristics.

    Main Methods:

    • Review of modern radical prostatectomy techniques and outcomes.
    • Analysis of prognostic factors including age, PSA levels, and Gleason score.
    • Discussion of expectant management strategies for low-volume, low-grade prostate cancer.

    Main Results:

    • Radical prostatectomy offers low perioperative morbidity and excellent long-term disease control.
    • Organ-confined prostate cancer can potentially be cured with local treatment.
    • Not all prostate cancers detected via screening become clinically significant.

    Conclusions:

    • Radical prostatectomy should be considered for elderly men with organ-confined prostate cancer due to its curative potential.
    • Expectant management is a viable strategy for select cases of screen-detected, low-grade prostate cancer.
    • Treatment decisions must balance curative intent with the patient's frailty and life expectancy.