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Updated: Jul 3, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Single coronary artery with spasm
Daisuke Utsunomiya1, Koichi Nakao, Yasuyuki Yamashita
1Diagnostic Imaging Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan. daisuke-utsunomiya@saiseikaikumamoto.jp
Insights
A rare single coronary artery anomaly caused chest pain in a 54-year-old woman. Multidetector computed tomography (CT) imaging diagnosed the condition, revealing coronary spasm rather than stenosis.
Area of Science:
- Cardiology
- Radiology
- Anatomical Variations
Background:
- A single coronary artery is a rare congenital anomaly with potential clinical significance.
- Coronary artery anomalies can present with diverse symptoms, including chest pain.
Observation:
- A 54-year-old woman presented with rest predominant chest pain.
- Diagnostic imaging revealed a single coronary artery.
- Computed tomography (CT) angiography was instrumental in visualizing the anomaly.
Findings:
- The CT angiographic images showed no evidence of coronary artery stenosis.
- Intracoronary acetylcholine infusion confirmed totally occlusive coronary spasm.
- This suggests vasospasm as the cause of symptoms in this coronary anomaly.
Implications:
- Multidetector CT is valuable for diagnosing and classifying coronary artery anomalies.
- Coronary artery anomalies, even without stenosis, can cause significant ischemic symptoms.
- Understanding the interplay of anomalies and vasospasm is crucial for patient management.
Abstract:
A single coronary artery is a rare and potentially serious anomaly. We present the case of a 54-year-old woman with chest pain predominantly at rest. A single coronary artery was demonstrated by 64-row multidetector computed tomography (CT) imaging, which is useful for the diagnosis and classification of coronary anomaly. In our case, no coronary artery stenosis was demonstrated on CT angiographic images, and totally occlusive coronary spasm was confirmed by intracoronary infusion of acetylcholine.
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