Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential associations of traditional and shape-based adiposity indices with steatosis and fibrosis risk in metabolic dysfunction-associated steatotic liver disease.

Journal of endocrinological investigation·2026
Same author

Severe Mycoplasma pneumoniae Pneumonia During the 2023-2024 European Re-Emergence: Why Severity Does Not Predict Macrolide Resistance.

Antibiotics (Basel, Switzerland)·2026
Same author

Sperm Imprinted Gene Methylation and DNA Fragmentation in ICSI Outcomes: A Pilot Study.

Epigenomes·2026
Same author

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.

Nature communications·2026
Same author

Atypical cutaneous manifestations of leprosy in a non-endemic country: a case report.

Travel medicine and infectious disease·2026
Same author

Pre-RAI Monocyte-to-Lymphocyte Ratio Predicts Early and Higher Recurrence Risk in Intermediate-Risk DTC, While PNI and NRI Show No Prognostic Value.

Clinical endocrinology·2026

Related Experiment Video

Updated: Jul 3, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
10:13

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

Hyaluronan and human endothelial cell behavior.

Anna Genasetti1, Davide Vigetti, Manuela Viola

  • 1Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell'Insubria, Varese, Italy.

Connective Tissue Research
|July 29, 2008
PubMed
Summary
This summary is machine-generated.

Hyaluronan (HA), a key extracellular matrix component, plays vital roles in cell functions. This review explores HA

More Related Videos

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
11:16

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Jul 3, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
10:13

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells

Published on: December 22, 2010

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
11:16

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration

Published on: February 10, 2023

Area of Science:

  • Biochemistry
  • Cell Biology
  • Vascular Biology

Background:

  • Hyaluronan (HA) is a non-sulfated glycosaminoglycan crucial for extracellular matrix structure and function.
  • Mammalian HA synthesis involves HAS1, HAS2, and HAS3, with daily catabolism by hyaluronidases.
  • HA and its oligosaccharides influence numerous biological processes, including cell proliferation, migration, and inflammation.

Purpose of the Study:

  • To review the presence and function of Hyaluronan (HA) in endothelial cells.
  • To elucidate the role of HA in normal endothelial cell biology.
  • To examine the involvement of HA during vascular injury.

Main Methods:

  • Literature review of existing studies on Hyaluronan (HA) and endothelial cells.
  • Analysis of data concerning HA synthesis, degradation, and biological functions.
  • Synthesis of information regarding HA's role in endothelial cell proliferation, migration, and leukocyte recruitment.

Main Results:

  • While HA's general functions are known, its specific presence in endothelium is under-reported.
  • HA significantly influences endothelial cell proliferation, migration, and new blood vessel formation.
  • HA plays a role in leukocyte recruitment to the vascular site.
  • HA oligosaccharides stimulate cytokine secretion and endothelial cell proliferation.

Conclusions:

  • Hyaluronan (HA) is integral to endothelial cell function in both normal physiological conditions and during vascular injury.
  • Further research is warranted to fully understand HA's presence and specific mechanisms within the endothelium.
  • HA represents a potential therapeutic target for vascular-related conditions.