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Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
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Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4

Renate Elenjord1, Hilde Ljones, Elisabeth Sundkvist

  • 1Department of Pharmacy, University of Tromsø, Tromsø, Norway. renate.elenjord@farmasi.uit.no

Connective Tissue Research
|July 29, 2008
PubMed

Insights

The S100A4 protein regulates matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs), impacting diseases like arthritis and cancer. This review explores S100A4

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • S100A4 protein, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) are implicated in various diseases.
  • Dysregulation of MMPs and TIMPs is a hallmark of pathological conditions including arthritis and cancer.
  • The precise role of S100A4 in modulating MMPs and TIMPs requires further elucidation.

Purpose of the Study:

  • To review in vitro and in vivo studies investigating the regulatory role of S100A4 on MMPs and TIMPs.
  • To summarize the biological and pathobiological consequences stemming from S100A4-mediated regulation of MMPs and TIMPs.
  • To consolidate current knowledge on S100A4's function in disease pathogenesis.

Main Methods:

  • Comprehensive literature search of in vitro and in vivo studies.
  • Analysis of experimental data linking S100A4 to MMP and TIMP expression and activity.
  • Synthesis of findings regarding the functional outcomes of S100A4-MMP/TIMP interactions.

Main Results:

  • Evidence demonstrates S100A4's involvement in the regulation of specific MMPs and TIMPs.
  • S100A4 influences cellular processes critical to disease progression, such as invasion and inflammation.
  • The interplay between S100A4, MMPs, and TIMPs contributes to the pathogenesis of arthritis and cancer.

Conclusions:

  • S100A4 plays a significant role in controlling the MMP/TIMP balance.
  • This regulation by S100A4 has direct implications for disease development and progression.
  • Targeting the S100A4-MMP/TIMP axis presents potential therapeutic strategies for S100A4-associated diseases.

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