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Updated: Jul 3, 2026

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
Published on: May 9, 2016
Breast cancer cells exhibit selective modulation induced by different collagen substrates
Ida Pucci-Minafra1, Nadia N Albanese, Gianluca Di Cara
1Dipartimento di Oncologia Sperimentale e Applicazioni Cliniche, Universita di Palermo, Palermo, Italy. idapucci@unipa.it
This review examines collagen matrix changes during breast cancer invasion. It explores how collagen substrates affect breast cancer cell behavior and protein expression.
Area of Science:
- Oncology
- Biochemistry
- Cell Biology
Background:
- Malignant tumors invade surrounding tissues during metastasis.
- Neoplastic cells breach the basal lamina, interacting with the connective tissue.
- Connective tissue undergoes significant alterations during cancer progression.
Purpose of the Study:
- To review changes in the collagenous matrix during breast cancer progression.
- To investigate the impact of various collagen substrates on breast cancer cell behavior.
- To explore the proteomic modulation induced by collagen in breast cancer cells.
Main Methods:
- Literature review of studies on collagen and breast cancer.
- Analysis of research on extracellular matrix modifications in breast cancer.
- Synthesis of findings on cancer cell-collagen interactions.
Main Results:
- Significant alterations occur in the collagenous matrix during breast cancer invasion.
- Different collagen substrates can influence breast cancer cell behavior, including migration and proliferation.
- Collagen composition affects the proteomic profile of breast cancer cells.
Conclusions:
- The collagenous matrix is a dynamic component in breast cancer progression.
- Targeting collagen-matrix interactions presents potential therapeutic strategies.
- Understanding cancer cell-collagen interactions is crucial for developing novel treatments.
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