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Updated: Jul 3, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde
Christelle Ghoneim1, Mahdhia Soula-Rothhut, Bernard Rothhut
1Laboratory of Biochemistry and Molecular Biology, Unité MEDyC, Faculty of Medicine URCA, Reims, France.
Abstract:
Thrombospondin-1 (TSP-1) is a member of a family of five structurally related extracellular glycoproteins that plays a major role in cell-matrix and cell-cell interactions. Due to its multifunctional nature and its ability to bind to a variety of cell surface receptors and matrix proteins, TSP-1 has been identified as a potential regulator of angiogenesis and tumor progression. In this review, we summarize recent results that we obtained in our laboratory dealing with the regulation of thombospondin-1 expression by epidermal growth factor and hepatocyte growth factor. Our results show that TSP-1 can have opposite effects on cell invasion depending upon the type of differentiated thyroid carcinoma studied.
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