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Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

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Related Experiment Video

Updated: Jul 3, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Silicates and bone fusion.

Walid Waked1, Jonathan Grauer

  • 1Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520-8071, USA.

Orthopedics
|July 30, 2008
PubMed
Summary
This summary is machine-generated.

Autologous bone grafting is standard but has side effects. Silicon-substituted calcium phosphates show promise as effective bone graft substitutes with valuable properties.

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A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
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A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

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Last Updated: Jul 3, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Autologous bone grafting is the current clinical standard for bone regeneration.
  • Despite its efficacy, autologous bone grafting is linked to donor-site morbidity and complications.
  • Developing alternative bone graft substitutes with osteoconductive, osteoinductive, and osteogenic potential is crucial.

Purpose of the Study:

  • To review existing bone grafting materials.
  • To evaluate silicon-substituted calcium phosphates as a viable alternative bone graft substitute.
  • To compare silicon-substituted calcium phosphates with current high-cost materials.

Main Methods:

  • Literature review of current bone grafting materials.
  • Analysis of the properties of silicon-substituted calcium phosphates.
  • Examination of the clinical applications and potential of silicon-substituted calcium phosphates.

Main Results:

  • Silicon-substituted calcium phosphates exhibit desirable properties for bone regeneration.
  • These materials present a competitive alternative to existing, costly bone graft substitutes.
  • The review highlights the potential of silicon-substituted calcium phosphates in various clinical settings.

Conclusions:

  • Silicon-substituted calcium phosphates offer a promising alternative to traditional bone grafts.
  • Further research and clinical validation are warranted to establish their role in orthopedic applications.
  • These materials could potentially reduce the comorbidities associated with autologous bone grafting.