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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
Published on: October 25, 2017
Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini
Yu Liu1, Akinori Kuzuya, Ruojie Sha
1Department of Chemistry, New York University, New York, New York 10003, USA.
Abstract:
We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.
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