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Updated: Jul 3, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Shape-programmable macromolecules.

Christian E Schafmeister¹, Zachary Z Brown, Sharad Gupta

¹Chemistry Department, Temple University, Philadelphia, Pennsylvania 19122, USA. meister@temple.edu

Accounts of Chemical Research

|July 30, 2008

Summary

This summary is machine-generated.

Researchers created novel macromolecules called bis-peptides, which have programmable shapes without protein folding. These synthetic structures offer precise control for future nanoscale molecular devices and catalysis.

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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

Area of Science:

Macromolecular chemistry
Synthetic biology
Nanotechnology

Background:

Proteins achieve function through specific 3D structures, formed via complex folding.
Current synthetic approaches often rely on unpredictable folding processes.
There is a need for macromolecules with engineered, predictable shapes.

Purpose of the Study:

To develop a method for synthesizing macromolecules with programmable shapes, avoiding protein folding.
To create synthetic macromolecules that mimic protein functions like catalysis and molecular recognition.
To engineer novel nanostructures for potential applications in molecular devices.

Main Methods:

Development of bis-amino acid monomers as synthetic building blocks.
Coupling of bis-amino acids via amide bonds to form spiroladder oligomers (bis-peptides).
Characterization of bis-peptide nanostructures and their conformational properties.

Main Results:

Successful synthesis of water-soluble bis-peptides with well-defined 3D structures.
Bis-peptides utilize fused rings and stereochemistry for shape determination, independent of folding.
Demonstrated a metal-exchange-controlled molecular actuator based on bis-peptides.

Conclusions:

Bis-peptides offer a novel, predictable route to constructing macromolecules with defined shapes.
These synthetic macromolecules can be functionalized for precise presentation of chemical groups.
Bis-peptides hold promise for multifunctional catalysis, molecular recognition, and nanoscale devices.