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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

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Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
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A PASport to cellular proliferation.

Eitan Zlotorynski1, Reuven Agami

  • 1The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

Cell
|July 30, 2008
PubMed
Summary
This summary is machine-generated.

Alternative polyadenylation generates messenger RNA (mRNA) variants with distinct 3' untranslated regions. This process is linked to microRNA regulation and cellular proliferation, impacting gene expression globally.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gene Regulation

Background:

  • Alternative polyadenylation (APA) generates distinct messenger RNA (mRNA) isoforms.
  • These isoforms possess varying 3' untranslated regions (3' UTRs).
  • The functional implications of APA, particularly in gene regulation, are an active area of research.

Purpose of the Study:

  • To investigate the connection between alternative polyadenylation and microRNA-mediated gene regulation.
  • To explore the role of APA in the global program of cellular proliferation.

Main Methods:

  • Analysis of mRNA isoforms with different 3' UTRs.
  • Examination of microRNA binding sites within these isoforms.
  • Correlation of APA patterns with cellular proliferation rates.

Main Results:

  • Evidence suggests alternative polyadenylation sites are associated with microRNA regulation.
  • APA contributes to a broader regulatory mechanism governing cellular proliferation.
  • Specific mRNA isoforms generated by APA may be targeted by microRNAs to control gene expression.

Conclusions:

  • Alternative polyadenylation plays a significant role in microRNA-mediated gene expression control.
  • APA is implicated as a key component of the cellular proliferation program.
  • Understanding APA-microRNA interactions provides insights into the regulation of cell growth and division.