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Structural insight into pH-induced conformational changes within the native human transthyretin tetramer

Satheesh K Palaninathan1, Nilofar N Mohamedmohaideen, William C Snee

  • 1Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

Journal of Molecular Biology
|July 30, 2008
PubMed
Summary

Acidification of transthyretin (TTR) causes structural changes, particularly in the EF helix-loop region, leading to tetramer destabilization and amyloid fiber formation. These findings reveal key early steps in TTR amyloidogenesis.

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