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Updated: Jul 3, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans
Published on: June 25, 2013
Central prostaglandins in food intake regulation
Kousaku Ohinata1, Masaaki Yoshikawa
1Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. ohinata@kais.kyoto-u.ac.jp
Abstract:
Prostaglandin (PG) E(2) and PGD(2), produced in the mammalian central nervous system, are known to have a variety of central actions on sleep, body temperature, and pain response via G-protein-coupled seven-transmembrane receptors. We found that centrally administered PGE(2) suppressed food intake via the EP(4) receptor, whereas PGD(2) increased food intake via the DP(1) receptor coupled to the neuropeptide Y Y(1) receptor. In this review, we summarize roles of central PGs in food intake regulation and discuss the relation between PGs and neuropeptides controlling food intake.
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