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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines
Shaukath Ara Khanum1, Noor Fatima Khanum, M Shashikanth
1Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore, Karnataka 570 005, India. shaukathara@yahoo.co.in
Abstract:
A series of potential biologically active 2-aryloxy methyl oxazolines 3a-n have been synthesized from substituted hydroxybenzenes 1a-n with good chemical yield. The compounds 3a-n were screened for their anti-inflammatory, ulcerogenic, cyclooxygenase activities and also for their acute toxicity. The potency of the compounds was compared with that of the standard drugs, aspirin and phenyl butazone. The outcome indicates that compounds 3b (48.2%), 3h (48.5%) and 3l (46.5%) offered significant anti-inflammatory activity with low ulcerogenic activity than the standard drugs.
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