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Infinium Assay for Large-scale SNP Genotyping Applications
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Unique among unique. Is it genetically determined?

M Gonzalez-Freire1, C Santiago, Z Verde

  • 1Universidad Europea de Madrid, Spain.

British Journal of Sports Medicine
|July 30, 2008
PubMed
Summary
This summary is machine-generated.

Elite endurance performance requires a favorable genetic makeup and significant environmental factors. This study analyzed the genes of a cross-country champion, finding his genotype uniquely suited for world-class running.

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Area of Science:

  • Sports Science
  • Human Genetics
  • Exercise Physiology

Background:

  • The cross-country world championship provides a model for studying elite endurance athletic capacity.
  • Genetic factors are hypothesized to influence endurance performance traits.

Purpose of the Study:

  • To investigate the genotype combination of a cross-country world champion.
  • To compare the champion's genotype with other world-class runners.
  • To identify genetic markers associated with top-level endurance performance.

Main Methods:

  • Genotyping of seven candidate genes (ACTN3, ACE, PPARGC1A, AMPD1, CKMM, GDF8, HFE) in polymorphisms.
  • Comparison of the champion's genotype with eight other world-class runners.
  • Analysis of genetic endowment in relation to endurance phenotype.

Main Results:

  • The cross-country champion possessed a unique genotype combination theoretically optimal for endurance running.
  • This genotype differed from the other world-class runners studied.
  • The champion's genetic profile was favorable for achieving elite endurance performance.

Conclusions:

  • A favorable genetic endowment appears necessary for reaching the highest levels of running endurance.
  • Exceptional environmental factors, such as altitude living and training, are also crucial.
  • The combination of genetics and environment is key to elite endurance athletic success.