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Characteristics of pruritus in children on peritoneal dialysis

Nilgun Senturk1, Ozan Ozkaya, Sevil Aytekin

  • 1Department of Dermatology, Ondokuz Mayis University, School of Medicine, Samsun, Turkey. nilsenturk@yahoo.com

Nephron. Clinical Practice
|July 30, 2008
PubMed

Insights

Pruritus (itching) is common in children on peritoneal dialysis, but not usually severe. Higher levels of serum phosphorus, calcium-phosphorus product, parathyroid hormone, and C-reactive protein are linked to this itching.

Area of Science:

  • Pediatric Nephrology
  • Dermatology
  • Urology

Background:

  • Pruritus is a frequent complaint in patients with chronic kidney disease.
  • Understanding pruritus in pediatric patients undergoing peritoneal dialysis (PD) is crucial for improving their quality of life.

Purpose of the Study:

  • To characterize pruritus in pediatric patients receiving peritoneal dialysis.
  • To identify clinical and laboratory factors associated with pruritus in this population.

Main Methods:

  • A cohort of 27 pediatric patients (ages 5-18) on PD were assessed for pruritus.
  • Pruritus characteristics were documented, and intensity was measured using a visual analog scale.
  • Laboratory parameters including serum phosphorus (P), parathyroid hormone (PTH), and C-reactive protein (CRP) were compared between patients with and without pruritus.

Main Results:

  • Twenty-two percent of patients experienced pruritus.
  • Patients with pruritus had significantly higher serum P, calcium-x-phosphorus (Ca x P) product, PTH, and CRP levels.
  • Logistic regression identified P, Ca x P product, PTH, and CRP as independent factors associated with pruritus.

Conclusions:

  • Pruritus is a common symptom in children on PD, though often not severely bothersome.
  • Elevated serum P, Ca x P product, PTH, and CRP are significant contributors to uremic pruritus in pediatric PD patients.
Abstract

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