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Plasma protein thiols and total antioxidant power in pediatric nephrotic syndrome

Kadirvel Karthikeyan1, Indrajit Sinha, Krishnananda Prabhu

  • 1Department of Pediatrics, Kasturba Medical College and Hospital, Manipal, India.

Nephron. Clinical Practice
|July 30, 2008
PubMed

Insights

Children with nephrotic syndrome (NS) experience oxidative stress, impacting treatment response. Their antioxidant levels improve during remission, indicating a positive therapeutic effect.

Area of Science:

  • Biochemistry
  • Pediatric Nephrology
  • Oxidative Stress Research

Background:

  • Oxidative damage from free radicals is linked to kidney injury, particularly in nephrotic syndrome (NS).
  • This oxidative stress may affect how children with NS respond to medical treatments.

Purpose of the Study:

  • To investigate the antioxidant status in children with nephrotic syndrome.
  • To determine the relationship between oxidative stress markers and disease state (active vs. remission) in NS.
  • To assess the impact of NS on antioxidant capacity and its correlation with treatment response.

Main Methods:

  • Enrolled children with NS (active disease and remission) and healthy controls.
  • Measured plasma protein thiol levels and ferric-reducing/antioxidant power spectrophotometrically.
  • Assessed serum total protein, albumin, and urine protein levels.

Main Results:

  • Plasma protein thiols were significantly lower in active NS compared to controls and remission.
  • Ferric-reducing/antioxidant power was elevated in NS patients and remained high in remission.
  • Serum protein and albumin were reduced in NS patients; plasma thiols increased in remission, indicating treatment response.

Conclusions:

  • Nephrotic syndrome is characterized by significant alterations in antioxidant status, suggesting a pro-oxidant environment.
  • These oxidative changes may influence treatment efficacy and patient outcomes in pediatric NS.
Abstract

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