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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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The dystrobrevin-binding protein 1 gene: features and networks.

A Y Guo1, J Sun, B P Riley

  • 1Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

Molecular Psychiatry
|July 30, 2008
PubMed
Summary

The dystrobrevin-binding protein 1 (DTNBP1) gene, linked to schizophrenia, shows conserved structure but diverse noncoding regions across vertebrates. Its interactome reveals potential roles in biological systems, offering new research avenues.

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Area of Science:

  • Genetics and Molecular Biology
  • Neuroscience
  • Bioinformatics

Background:

  • The dystrobrevin-binding protein 1 (DTNBP1) gene is a key focus in schizophrenia susceptibility research.
  • Previous studies have explored DTNBP1's functional and associative roles, but a comprehensive review is lacking.

Purpose of the Study:

  • To systematically review DTNBP1 gene features, protein characteristics, and function-phenotype relationships.
  • To analyze DTNBP1 evolution, genetic variation, and molecular interactions using bioinformatics.

Main Methods:

  • Bioinformatic analysis of DTNBP1 across 13 vertebrate species.
  • Molecular evolutionary analysis and identification of conserved/diverse regions.
  • Construction and network analysis of the DTNBP1 interactome.

Main Results:

  • DTNBP1 exhibits conserved gene structure and protein-coding sequences but diverse noncoding regions.
  • Evolutionary analysis suggests DTNBP1 originated in chordates and matured in vertebrates, with no recent positive selection in primates.
  • The DTNBP1 interactome highlights roles in organelle biogenesis and identifies novel interacting molecules like retinoic acid and calmodulin.

Conclusions:

  • DTNBP1 likely possesses more alternative transcripts than currently known.
  • Genetic variations in DTNBP1 show significant population differences, exceeding case-control differences.
  • The DTNBP1 interactome provides crucial insights into its biological functions and potential therapeutic targets for psychiatric disorders.