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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jul 3, 2026

Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
07:48

Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds

Published on: July 9, 2021

[Neuroblastoma in children].

M Hörmann1

  • 1Abteilung allgemeine Radiologie und Kinderradiologie, Medizinische Universität Wien, Währingergürtel 18-20, A-1090 Wien, Osterreich. marcus.hoermann@meduniwien.ac.at

Der Radiologe
|July 30, 2008
PubMed
Summary

High-risk neuroblastoma, a common childhood cancer, has poor survival rates despite treatment. Re-evaluating diagnosis, staging, biology, and therapy is crucial for improving outcomes in this challenging disease.

Area of Science:

  • Pediatric Oncology
  • Cancer Biology
  • Tumor Pathology

Background:

  • Neuroblastomas exhibit diverse clinical presentations, from benign to aggressive malignant forms.
  • Over 50% of neuroblastomas are high-risk, characterized by frequent recurrence.
  • Current survival rates for high-risk neuroblastoma remain below 40% despite intensive multidisciplinary treatments.

Purpose of the Study:

  • To highlight the critical need for a comprehensive re-evaluation of the current medical approach to neuroblastoma.
  • To emphasize the importance of refining diagnostic and staging methods.
  • To underscore the necessity of advancing our understanding of tumor biology and pathology for improved therapeutic strategies.

Main Methods:

  • Analysis of extensive international study data spanning from the early 1970s.

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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

Related Experiment Videos

Last Updated: Jul 3, 2026

Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
07:48

Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds

Published on: July 9, 2021

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
05:10

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

  • Review of clinical presentations, diagnostic criteria, and staging protocols.
  • Examination of therapeutic outcomes and recurrence rates in high-risk neuroblastoma cases.

    • Main Results:

    • Data indicates significant heterogeneity in neuroblastoma clinical behavior.
    • High-risk neuroblastomas demonstrate a persistent challenge with high recurrence rates.
    • Existing therapeutic strategies have not sufficiently improved survival for high-risk pediatric neuroblastoma.

    Conclusions:

    • A fundamental reassessment of neuroblastoma diagnosis and staging is urgently required.
    • Deeper insights into neuroblastoma tumor biology and pathology are essential for therapeutic advancements.
    • International collaborative efforts are necessary to re-evaluate and optimize treatment planning for improved patient outcomes.