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Related Experiment Video

Updated: Jul 3, 2026

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Sleeve gastrectomy-a "food limiting" operation.

John Melissas¹, Markos Daskalakis, Sophia Koukouraki

¹Bariatric Unit Department of Surgical Oncology, Heraklion University Hospital, Medical School, University of Crete, 15 Delaporta St., Herarklion 71409, Crete, Greece. melissas@med.uoc.gr

Obesity Surgery

|July 30, 2008

Summary

Sleeve gastrectomy (SG) accelerates gastric emptying of solids long-term, aiding weight loss. This study confirms sustained effects on gastric motility and emptying rates 24 months post-surgery.

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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

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Published on: March 20, 2017

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Last Updated: Jul 3, 2026

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Area of Science:

Bariatric Surgery
Gastrointestinal Motility
Obesity Treatment

Background:

Sleeve gastrectomy (SG) is a popular bariatric procedure for weight loss and comorbidity resolution.
Evaluating the long-term clinical outcomes and gastric emptying post-SG is crucial.

Purpose of the Study:

To assess the clinical outcomes and gastric emptying of solid foods at 24 months following sleeve gastrectomy.
To determine if the observed changes in gastric emptying are sustained long-term.

Main Methods:

Prospective study of 14 morbidly obese patients (10 female, 4 male; median age 41, BMI 49.46 kg/m²).
Gastric emptying studies using radioisotopic technique performed pre-operatively, at 6 months, and 24 months post-SG in a subset of patients.
Weight and BMI were monitored throughout the 24-month follow-up period.

Main Results:

Significant weight and BMI reduction observed at 6, 12, and 24 months post-surgery.
Gastric emptying studies showed a significant decrease in T-lag phase and accelerated T1/2 (half emptying time) at 6 and 24 months post-SG (P < 0.05).
Percentage of gastric emptying (%GE) significantly increased post-surgery, with no significant differences between 6 and 24 months, indicating sustained effects.

Conclusions:

Sleeve gastrectomy consistently accelerates gastric emptying of solids in both the short and long term.
Accelerated gastric motility and potential alterations in gut hormones contribute to the weight loss efficacy of SG.
The findings support SG as an effective 'food limiting' operation with sustained impact on gastric function.