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Updated: Jul 3, 2026
08:53
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
Published on: August 31, 2016
[Chronic renal failure after hematopoietic stem cell transplantation]
G Boscutti1, S Pizzolitto, F Patriarca
1SOC di Nefrologia e Dialisi ASS Isontina, Ospedali di Gorizia e Monfalcone, Gorizia, Italy. giuliano.boscutti@ass2.sanita.fvg.it
Summary
Late-onset renal complications after hematopoietic stem cell transplantation (HSCT) can cause chronic kidney failure. Kidney biopsy is crucial for diagnosing thrombotic microangiopathy post-HSCT and guiding treatment.
Area of Science:
- Nephrology
- Hematology
- Oncology
Context:
- Hematopoietic stem cell transplantation (HSCT) is a standard procedure for hematologic disorders.
- Renal complications following HSCT can significantly impact patient outcomes.
- Late-occurring kidney issues, particularly chronic renal failure, are a recognized concern.
Purpose:
- To discuss the characteristics of late-onset renal complications after HSCT.
- To differentiate these complications from other thrombotic microangiopathies and renal diseases.
- To highlight the role of kidney biopsy in diagnosis and management.
Summary:
- Progressive chronic renal failure, hypertension, and urinary sediment changes characterize late HSCT-related renal complications.
- Pathological findings often reveal thrombotic microangiopathy, which may not align with clinical presentation.
- Potential causes include total body irradiation, chemotherapy, calcineurin inhibitors, and infections.
Impact:
- Accurate diagnosis via kidney biopsy is essential for prognosis and treatment planning.
- Further research is needed to clarify the nosological classification, prognosis, and optimal therapies.
- Understanding these complications can improve long-term care for HSCT survivors.
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