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Related Experiment Videos

A novel, self-correcting membrane coating technique.

H R Bhagat1, R W Mendes, E Mathiowitz

  • 1Department of Pharmaceutics, University of Maryland, College Park 20742.

Pharmaceutical Research
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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A new diffusion-controlled interfacial complexation coating method creates uniform, defect-free films on solid dosage forms. This novel process ensures zero-order drug release from coated tablets.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Developing uniform, defect-free coatings on solid dosage forms is crucial for controlled drug delivery.
  • Existing coating methods can be complex and may not always ensure consistent film quality.

Purpose of the Study:

  • To introduce and characterize a novel coating process: diffusion-controlled interfacial complexation.
  • To demonstrate the formation of uniform, defect-free coatings on solid dosage forms.
  • To evaluate the drug release profile of coated dosage forms.

Main Methods:

  • A chemical reaction between an incorporated reactant (calcium acetate) and a polymer solution (algin) formed an insoluble film.
  • The coating process, diffusion-controlled interfacial complexation, was mathematically modeled.
  • Coating uniformity, film thickness, film weight, and reactant depletion were characterized.

Related Experiment Videos

  • Compressed tablets were coated and their release profiles assessed.

    • Main Results:

    • The diffusion-controlled interfacial complexation process successfully formed uniform, defect-free coatings.
    • Mathematical characterization provided insights into film formation kinetics.
    • Coated tablets exhibited zero-order drug release in distilled water.

    Conclusions:

    • Diffusion-controlled interfacial complexation is a viable novel coating technology for solid dosage forms.
    • This method offers precise control over film formation and drug release.
    • The process holds potential for developing advanced drug delivery systems.