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Updated: Jul 3, 2026
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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
[Research progress on interactions between luteolin (glucosides) and drug-metabolizing enzyme]
Jing-Yan Ying1, Shao-Jun Gu, Tong-Wei Yao
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|July 31, 2008
Summary
Luteolin and its glucosides interact with drug-metabolizing enzymes, affecting their activity. Understanding these interactions is crucial for the safe and effective clinical use of luteolin-based treatments.
Area of Science:
- Pharmacology
- Drug Metabolism
- Biochemistry
Background:
- Luteolin, a flavonoid, undergoes metabolism primarily via Phase II enzymes.
- Glucosides of luteolin are hydrolyzed to aglycone in the intestine before absorption and metabolism.
Purpose of the Study:
- To summarize the interactions between luteolin (and its glucosides) and drug-metabolizing enzymes.
- To highlight the significance of these interactions for clinical applications.
Main Methods:
- Literature review of recent research.
- Inclusion of original research findings.
Main Results:
- Luteolin induces CYP3A and inhibits CYPIA, 1B, and 2E.
- Luteolin inhibits CYP2B6, CYP2C9, and CYP2D6.
- Luteolin modulates UGTs, SULTs, and inhibits ABC transporters.
Conclusions:
- Luteolin exhibits complex interactions with various drug-metabolizing enzymes and transporters.
- Knowledge of these interactions is vital for guiding the clinical use of luteolin.
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