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Updated: Jul 3, 2026
08:08
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Proteomic contributions to personalized cancer care
John M Koomen1, Eric B Haura, Gerold Bepler
1H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA. john.koomen@moffitt.org
Molecular & Cellular Proteomics : MCP
|July 31, 2008
Summary
Proteomics, using mass spectrometry, aids in discovering cancer biomarkers and therapeutic targets. This advances personalized medicine by translating basic science into clinical practice for better patient outcomes.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Cancer's complexity extends beyond clinical signs, with many molecular mechanisms unclear.
- Targeted cancer treatments and personalized medicine require deeper understanding of molecular underpinnings.
- Current strategies lack widespread molecularly targeted treatments for most cancers.
Purpose of the Study:
- To highlight proteomics' role in advancing cancer research and personalized medicine.
- To demonstrate how proteomics facilitates the discovery of biomarkers and therapeutic targets.
- To illustrate the translation of basic science discoveries into clinical applications.
Main Methods:
- Utilizing biological mass spectrometry for proteome analysis.
- Integrating proteomic data with existing patient care and research initiatives.
- Presenting case studies in ovarian cancer, lung cancer, and multiple myeloma.
Main Results:
- Discovery of diagnostic biomarkers for ovarian cancer.
- Development of novel treatment strategies for lung cancer.
- Improved monitoring of prognosis and relapse in multiple myeloma.
Conclusions:
- Proteomics is crucial for identifying cancer biomarkers and therapeutic targets.
- Proteomics enables the translation of basic research into personalized cancer medicine.
- Mass spectrometry-driven proteomic analysis offers significant potential for improving cancer patient care.
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