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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Transient osteoporosis.

Anastasios V Korompilias1, Apostolos H Karantanas, Marios G Lykissas

  • 1Department of Orthopaedic Surgery, University of Ioannina, Ioannina, PC 45110, Greece.

The Journal of the American Academy of Orthopaedic Surgeons
|July 31, 2008
PubMed
Summary

Transient osteoporosis, a condition causing bone marrow edema, typically affects middle-aged men

Area of Science:

  • Orthopedics
  • Radiology
  • Rheumatology

Background:

  • Transient osteoporosis is a self-limiting condition characterized by bone marrow edema.
  • It commonly affects the hip, knee, and ankle in middle-aged men.
  • The exact cause of transient osteoporosis is currently unknown.

Purpose of the Study:

  • To highlight the diagnostic features of transient osteoporosis.
  • To emphasize the importance of differentiating it from other conditions with similar imaging findings.
  • To underscore the need for timely and accurate diagnosis to guide appropriate management.

Main Methods:

  • Review of clinical presentations and characteristic imaging findings.
  • Discussion of differential diagnoses for bone marrow edema.

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

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  • Emphasis on the role of Magnetic Resonance Imaging (MRI) in diagnosis and monitoring.

    • Main Results:

    • Transient osteoporosis is diagnosed based on bone marrow edema, often affecting the hip, knee, or ankle.
    • Plain radiographs may show regional osseous demineralization.
    • MRI is crucial for early diagnosis and tracking disease progression.

    Conclusions:

    • The self-limited nature distinguishes transient osteoporosis from other bone marrow edema conditions.
    • Early differentiation from osteonecrosis is vital to prevent unnecessary interventions.
    • Accurate diagnosis ensures appropriate treatment, especially distinguishing from conditions requiring surgical intervention.