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Pulmonary emphysema: histopathologic correlation with minimum intensity projection imaging, high-resolution computed
Shiro Satoh1, Yoshio Kitazume, Shinichi Taura
1Department of Radiology, Ohme Municipal General Hospital, Ohme City, Tokyo, Japan. satou-s@mghp.ome.tokyo.jp
Journal of Computer Assisted Tomography
|July 31, 2008
Summary
Minimum-intensity projection (minIP) imaging is a superior method for quantifying emphysema compared to high-resolution computed tomography (HRCT). Both techniques, along with pulmonary function tests, were validated against histopathologic examination.
Area of Science:
- Pulmonary Medicine
- Radiology
- Pathology
Background:
- Emphysema quantification is crucial for diagnosis and management.
- Accurate imaging biomarkers are needed to assess disease severity.
Purpose of the Study:
- To prospectively evaluate minimum-intensity projection (minIP) imaging, high-resolution (HR) computed tomography (CT), and pulmonary function tests for emphysema quantification.
- To compare these methods against histopathologic examination.
Main Methods:
- MinIP and HRCT imaging data from 23 patients were analyzed.
- Relative lung areas with specific attenuation values and percentiles were calculated.
- Pulmonary function tests and histopathologic measurements (mean alveolar perimeter) were compared.
Main Results:
- MinIP at -990 HU and the fifth percentile showed the strongest correlation with mean alveolar perimeter.
- HRCT at -1000 HU and the seventh percentile also correlated well.
- MinIP demonstrated a significantly higher extension (0%-51%) in quantifying emphysema compared to HRCT (1%-21%).
Conclusions:
- MinIP imaging is a more predictive tool for quantifying emphysema than HRCT.
- Diffusion capacity of lung for carbon monoxide is also a valid index for emphysema assessment.
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