Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hughes-Stovin syndrome (HSS) preliminary diagnostic criteria: a paradigm shift in managing pulmonary vasculitis in HSS and Behçet's disease (BD). On behalf of the HSS International Study Group (HSSISG) : Reply on Tahir Saygın Öğüt and Veli Yazısız "Comments on the proposed diagnostic criteria for Hughes-Stovin syndrome: the role of Behçet syndrome" (CLRH-D-26-01350).

Clinical rheumatology·2026
Same author

Hughes-Stovin syndrome (HSS) preliminary diagnostic criteria: a report by the HSS International Study Group (HSSISG).

Clinical rheumatology·2026
Same author

In reply to: "Post-COVID lung injury and the need for longitudinal histology".

Croatian medical journal·2026
Same author

Lung Transplantation in Idiopathic Pulmonary Fibrosis Patients in the European MultiPartner IPF Registry: Challenges for Health Equity.

Biomedicines·2025
Same author

Lung long distance: histopathological changes in lung tissue after COVID-19 pneumonia.

Croatian medical journal·2025
Same author

Short- and long-term clinical outcomes of nintedanib therapy in IPF patients with different phenotypes: A retrospective registry-based study.

Respiratory medicine·2024

Related Experiment Video

Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Diffuse pulmonary ossification: an unusual interstitial lung disease.

Tatjana Peros-Golubicić1, Jasna Tekavec-Trkanjec

  • 1University Hospital for Lung Diseases Jordanovac, Zagreb, Croatia. tperos-golubicic@net.hr

Current Opinion in Pulmonary Medicine
|July 31, 2008
PubMed
Summary

Diffuse pulmonary ossification, a rare lung condition with bone fragments, is often missed during diagnosis. Early recognition is key for understanding its causes and developing new treatments.

More Related Videos

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Related Experiment Videos

Last Updated: Jul 3, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Radiology

Background:

  • Diffuse pulmonary ossification (DPO) is a rare condition characterized by bone deposition in lung tissue.
  • It can be idiopathic or secondary to chronic pulmonary or cardiac diseases.
  • Historically diagnosed primarily via autopsy, DPO remains underrecognized clinically.

Observation:

  • Tissue injury and an alkaline environment promote calcium salt precipitation and profibrogenic cytokine activation.
  • Alveolar bleeding contributes to interstitial metallic deposition, attracting calcium and multinucleated giant cells.
  • High-resolution computed tomography (HRCT) with mediastinal window settings aids in detecting bone density lesions.

Findings:

  • DPO results from interacting factors, with tissue injury being a primary trigger.
  • HRCT offers a minimally invasive diagnostic approach for identifying bone lesions.
  • Emerging evidence suggests potential therapeutic roles for bisphosphonates and warfarin in managing heterotopic ossification.

Implications:

  • Underdiagnosis of DPO is likely underestimated, especially in aging populations with chronic diseases.
  • Timely diagnosis is crucial for advancing the understanding of DPO pathogenesis and natural history.
  • Improved diagnostic awareness may lead to novel therapeutic strategies for diffuse pulmonary ossification.