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Clinical effectiveness of ototopical application of mupirocin ointment in methicillin-resistant Staphylococcus aureus

Masayuki Furukawa1, Akira Minekawa, Takuo Haruyama

  • 1Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|July 31, 2008
PubMed
Abstract

Insights

Mupirocin ointment effectively eliminated Methicillin-resistant Staphylococcus aureus (MRSA) in ear infections, showing superior results compared to ofloxacin ear drops. This treatment is a safe and useful option for MRSA otorrhea without causing hearing loss.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Microbiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) otorrhea is a growing concern, particularly with tympanic membrane perforations and post-surgical infections.
  • Preoperative dry ear conditions are critical factors influencing surgical outcomes in otorrhea cases.

Purpose of the Study:

  • To evaluate the efficacy of mupirocin ointment versus ofloxacin ear drops in controlling MRSA otorrhea.
  • To assess the safety and effectiveness of ototopical treatments for MRSA ear infections before and after surgery.

Main Methods:

  • A randomized study involving 26 patients with MRSA otorrhea.
  • Mupirocin ointment applied locally (1-4 times over 2-3 weeks) vs. ofloxacin ear drops administered daily at home for 2-3 weeks.

Main Results:

  • Complete eradication of MRSA was achieved in 100% of patients treated with mupirocin ointment.
  • Mupirocin showed significantly higher improvement and cure rates (p < 0.001) compared to ofloxacin (40% improvement + cure rate).
  • Pure-tone audiometry confirmed no adverse effects on hearing acuity with mupirocin treatment.

Conclusions:

  • Minimally essential local application of mupirocin ointment is a highly effective ototopical agent for MRSA otorrhea.
  • Mupirocin demonstrates excellent efficacy against MRSA otorrhea with no evidence of ototoxicity.

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