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Updated: Jul 3, 2026

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
The NIH-NIAID schistosomiasis resource center
Fred A Lewis1, Yung-San Liang, Nithya Raghavan
1Biomedical Research Institute, Rockville, Maryland, United States of America. flewis@afbr-bri.com
Maintaining the complex life cycle of schistosome parasites for research is challenging and costly. A centralized resource, established by the National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID), provides essential life stages, saving researchers time and funds.
Area of Science:
- Parasitology
- Tropical Disease Research
- Infectious Disease
Background:
- Schistosomiasis research requires maintaining the parasite's life cycle, involving mammalian and snail hosts.
- This process is resource-intensive, posing significant financial and logistical challenges for investigators, especially new ones.
- Limited lab space and experienced personnel further complicate parasite life cycle maintenance.
Purpose of the Study:
- To review the historical context and scope of a centralized resource for schistosome life stages.
- To highlight the resource's impact on the research community and its cost-saving benefits.
- To inform investigators, particularly those new to the field, about available materials and support.
Main Methods:
- Historical review of the NIH-NIAID centralized resource contract.
- Description of available schistosome species and life stages.
- Assessment of the resource's impact on tropical disease research funding and efficiency.
Main Results:
- The centralized resource has provided significant cost savings to both the funding agency and researchers.
- It enables investigators to redirect funds and personnel towards specific research objectives.
- The resource has facilitated research by overcoming the difficulties of maintaining parasite life cycles.
Conclusions:
- The NIH-NIAID resource is a valuable asset for schistosomiasis research, mitigating the challenges of parasite life cycle maintenance.
- Awareness of this resource can significantly benefit researchers by providing essential materials and support.
- The resource offers potential for future contributions to evolving research interests in tropical medicine.
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