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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...

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Related Experiment Video

Updated: Jul 3, 2026

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function
10:06

High Resolution Whole Mount In Situ Hybridization within Zebrafish Embryos to Study Gene Expression and Function

Published on: October 19, 2013

Cadherin-7 function in zebrafish development.

Qin Liu1, James A Marrs, Richard L Londraville

  • 1Department of Biology, University of Akron, Akron, OH 44325, USA. qliu@uakron.edu

Cell and Tissue Research
|July 31, 2008
PubMed
Summary
This summary is machine-generated.

Cadherin-7 is essential for zebrafish notochord development. This study reveals its critical role in forming this vital embryonic structure, unlike its limited impact on the central nervous system.

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Using Whole Mount in situ Hybridization to Link Molecular and Organismal Biology
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Using Whole Mount in situ Hybridization to Link Molecular and Organismal Biology

Published on: March 31, 2011

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Adhesion

Background:

  • Cadherin cell adhesion molecules are vital for vertebrate development.
  • Classical type I cadherins have been extensively studied, but classical type II cadherins, such as cadherin-7, are less understood.
  • Cadherin-7 mRNA shows dynamic expression in embryonic zebrafish central nervous system and notochord.

Purpose of the Study:

  • To investigate the function of cadherin-7 in the development of the zebrafish central nervous system and notochord.
  • To elucidate the role of classical type II cadherins in vertebrate embryogenesis.

Main Methods:

  • Utilized antisense morpholino oligonucleotides (MO) specific to cadherin-7.
  • Injected MO into zebrafish embryos to disrupt cadherin-7 function.
  • Analyzed the impact of cadherin-7 knockdown on notochord and central nervous system development.

Main Results:

  • Notochord development was significantly disrupted in cadherin-7 morphant zebrafish embryos.
  • No gross defects were observed in the central nervous system development of MO-injected embryos.
  • Cadherin-7 plays a crucial role in zebrafish notochord formation.

Conclusions:

  • Cadherin-7 is indispensable for normal zebrafish notochord development.
  • The study highlights a specific role for classical type II cadherins in embryonic patterning.
  • Further research can explore the precise molecular mechanisms of cadherin-7 in notochord morphogenesis.