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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

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Articles linked to this work by shared authors, journal, and citation graph.

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Related Experiment Video

Updated: Jul 3, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Current approaches and challenges in making a bio-tooth.

Jinhua Yu1, Junnan Shi, Yan Jin

  • 1Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, P.R. China.

Tissue Engineering. Part B, Reviews
|July 31, 2008
PubMed
Summary

Creating a biological tooth (bio-tooth) using tissue engineering offers a promising solution for tooth loss. Key challenges in shape, size, and immune rejection must be overcome for successful bio-tooth regeneration.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Developmental Biology

Background:

  • Tooth loss negatively impacts oral function and facial aesthetics.
  • Current artificial implants and nonbiological materials have limitations, including reduced quality of life and immunological rejection.
  • The concept of a biological tooth (bio-tooth) engineered from a patient's own cells represents an ideal, long-sought solution.

Purpose of the Study:

  • To review current advancements in tooth regeneration.
  • To highlight critical challenges in bio-engineered tooth reconstruction.
  • To discuss the potential of tissue engineering for creating functional bio-teeth.

Main Methods:

  • Review of recent literature on tissue engineering, stem cell biology, developmental biology, molecular genetics, and bionics.
  • Analysis of challenges in bio-tooth development, including shape determination, size control, and graft integration.
  • Focus on strategies for achieving successful tooth regeneration.

Main Results:

  • Significant progress in regenerative medicine has brought bio-engineered teeth closer to reality.
  • Several key obstacles remain, including controlling tooth shape and size, ensuring adequate dental epithelium, directing growth and eruption, and preventing graft rejection.
  • The review consolidates current approaches and identifies critical areas for future research.

Conclusions:

  • Tissue engineering holds immense potential for creating biological teeth to treat tooth loss.
  • Overcoming challenges in bio-tooth development is crucial for clinical translation.
  • Further research is needed to address the complexities of regenerating functional, integrated bio-teeth.