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Updated: Jul 3, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
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Published on: November 23, 2016

Structure-activity study of phosphoramido acid esters as acetylcholinesterase inhibitors

Saied Ghadimi1, Ali Asghar Ebrahimi Valmoozi, Mehrdad Pourayoubi

  • 1Department of Chemistry, Imam Hossein University, Tehran, Iran. Ghadimi_Saied@yahoo.com

Journal of Enzyme Inhibition and Medicinal Chemistry
|July 31, 2008
PubMed

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
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