Inhibition of LFA-1 mediated T-cell motility by naphthoquinones
Helen Sheridan1, Ingrid Hook, Cora Nestor
1Trinity College Dublin, School of Pharmacy & Pharmaceutical Sciences, Panoz Institute, Dublin, Ireland. hsheridn@tcd.ie
Planta Medica
|July 31, 2008
Abstract:
An in vitro T-cell migration assay has been established that can be used to study the effects of compounds on the development of T-cell polarisation with HuT-78 T lymphocytes. This assay indicates the ability of compounds tested to inhibit the inflammatory response by decreasing LFA-1-mediated T-cell motility. The effect of a series of naturally occurring quinone isolates on motility has been evaluated in this assay. Distinct differences have been observed between naphthoquinones, dihydrofuranonaphthoquinones and anthraquinones.
