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Related Experiment Video

Updated: Jul 3, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Quantifying cerebral changes in adolescence with MRI and deformation based morphometry.

William R Riddle1, Susan C DonLevy, Curtis A Wushensky

  • 1Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232-2675, USA. bill.riddle@vanderbilt.edu

Journal of Magnetic Resonance Imaging : JMRI
|July 31, 2008
PubMed
Summary
This summary is machine-generated.

Brain structure significantly changes from childhood to adolescence, with gray matter decreasing and white matter increasing substantially. These findings highlight key developmental shifts in specific brain regions during maturation.

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Last Updated: Jul 3, 2026

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Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Brain maturation involves dynamic structural alterations from childhood through adolescence.
  • Understanding these changes is crucial for identifying typical developmental trajectories and potential neurological deviations.

Purpose of the Study:

  • To quantify structural brain changes during the transition from childhood to adolescence.
  • To identify specific brain regions undergoing significant gray and white matter volume modifications.

Main Methods:

  • Utilized serial, three-dimensional T1-weighted MRI scans from eight subjects scanned 6–7 years apart.
  • Employed nonrigid deformation fields to calculate regional volume changes and generated color overlays for visualization.

Main Results:

  • Observed a decrease in gray matter volume by up to 60% and an increase in white matter volume by up to 250%.
  • Identified the caudate nucleus, putamen, and thalamus as key areas of gray matter reduction.
  • Highlighted the forceps minor, forceps major, and internal capsule as regions with significant white matter expansion.

Conclusions:

  • Deformation-based morphometry using serial MRI is an effective method for studying regional brain structural changes during maturation.
  • The study quantifies significant gray and white matter volume shifts, providing insights into adolescent brain development.