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Updated: Jul 3, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
Jacquelyn J Maher1, Pablo Leon, James C Ryan
1Department of Medicine, University of California, San Francisco, CA, USA. jmaher@medsfgh.ucsf.edu
Abstract:
Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease.
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