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Updated: Jul 3, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Phosphine-free Cp*Ru(diamine) catalysts in the hydrogenation of imines
Pradeep Cheruku1, Tamara L Church, Pher G Andersson
1Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, Husargatan 3, BMC, 75123, Uppsala, Sweden.
Abstract:
We previously reported the phosphine-free Cp*Ru(diamine)-catalyzed hydrogenation of aryl methyl ketones. Herein we present the first report of ruthenium-diamine-catalyzed imine hydrogenation to form amines. The most effective catalyst, I/KOtBu, completely converted several imines to amines at room temperature. The effect of electron-donating and -withdrawing groups on the reaction was investigated using a suitable series of substrates. The asymmetric version of the reaction was studied for two substrates, and the chiral amine products could be obtained in moderate enantiomeric excess.
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