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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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Published on: January 26, 2019

A new pH-switchable dimannosyl[c2]daisy chain molecular machine.

Frédéric Coutrot1, Camille Romuald, Eric Busseron

  • 1Institut des Biomolécules Max Mousseron, UMR 5247CNRS-Universités Montpellier 2 et 1, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 34296 Montpellier Cedex 5, France. frederic.coutrot@univ-montp2.fr

Organic Letters
|August 1, 2008
PubMed
Summary

A novel dimannosyl daisy chain molecular machine was synthesized. Its structure can be reversibly switched between stretched and contracted states by altering the pH, controlling mannosyl stopper positioning.

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Area of Science:

  • Supramolecular Chemistry
  • Molecular Machines
  • Organic Synthesis

Background:

  • Molecular machines offer precise control over nanoscale movements.
  • Daisy chain architectures are a key motif in designing complex molecular systems.
  • Controlling the spatial arrangement of components is crucial for function.

Purpose of the Study:

  • To synthesize a novel dimannosyl daisy chain molecular machine.
  • To investigate pH-responsive conformational changes in the molecular machine.
  • To demonstrate controllable localization of molecular stoppers.

Main Methods:

  • Multi-step organic synthesis for molecular machine construction.
  • Spectroscopic techniques for structural characterization.
  • pH-titration studies to monitor conformational changes.

Main Results:

  • Successful preparation of the dimannosyl daisy chain molecular machine with ammonium and triazolium stations.
  • Demonstration of reversible switching between stretched and contracted states.
  • Correlation of pH variations with the precise localization of mannosyl stoppers.

Conclusions:

  • The synthesized molecular machine exhibits controllable, pH-dependent conformational dynamics.
  • This work provides a foundation for designing sophisticated molecular devices with tunable properties.
  • The dimannosyl daisy chain represents a promising platform for advanced molecular engineering.