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Published on: January 29, 2018
Bone architectural and structural properties after 56Fe26+ radiation-induced changes in body mass
J S Willey1, L G Grilly, S H Howard
1Department of Bioengineering, Clemson University, Clemson, South Carolina, USA.
Radiation Research
|August 1, 2008
Summary
High-energy, high-charge (HZE) radiation, like iron ions, can harm shielded bones. Even when protected, bone structure deteriorates with increased radiation exposure, impacting bone mass and microarchitecture.
Area of Science:
- Space science
- Radiation biology
- Orthopedics
Background:
- Space radiation, including high-energy, high-charge (HZE) ions like iron, poses risks to astronauts.
- Previous studies showed significant bone loss after whole-body HZE irradiation.
Purpose of the Study:
- To investigate the effects of HZE radiation on shielded bones.
- To determine if HZE radiation exposure alters bone morphology in areas excluded from direct irradiation.
Main Methods:
- Male Sprague-Dawley rats were exposed to 0, 1, 2, or 4 Gy of iron ions ((56)Fe(26+)).
- Hind limbs and pelvis were shielded from direct radiation exposure.
- Bone morphology and body mass were assessed after 9 months.
Main Results:
- Significant dose-dependent reductions in trabecular bone volume, connectivity, and thickness were observed in shielded proximal tibiae.
- Reduced body mass in irradiated rats correlated with deficits in both trabecular and cortical bone parameters.
- The reduction in trabecular thickness at 4 Gy was not solely attributable to decreased body mass.
Conclusions:
- Exposure to (56)Fe(26+) ions can negatively impact the microarchitecture of shielded bones.
- Reduced body mass is a significant factor associated with HZE radiation-induced bone deficits.
- Further research is needed to understand the mechanisms behind radiation-induced bone loss in shielded areas.
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