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Challenges with using chronic disease endpoints in setting dietary reference intakes.

Paula R Trumbo¹

¹Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, MD 20740, USA. paula.trumbo@fda.hhs.gov

Nutrition Reviews

|August 1, 2008

Summary

Dietary guidelines in the US now consider chronic disease risk, but Recommended Dietary Allowances (RDAs) still focus on general health. Challenges exist in applying chronic disease data to set DRIs.

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Area of Science:

Nutrition Science
Public Health Policy
Dietary Guidelines

Background:

Recommended Dietary Allowances (RDAs) in the US, established in 1941, primarily aim to maintain population health.
Growing evidence links diet to chronic disease risk reduction, prompting a shift towards incorporating these endpoints in dietary reference intakes (DRIs).

Purpose of the Study:

To discuss the application of chronic disease endpoints in setting DRIs.
To identify challenges associated with using chronic disease data for DRIs.

Main Methods:

Review of current practices in setting DRIs.
Analysis of the integration of chronic disease risk data into dietary guidelines.

Main Results:

No RDAs established during the recent DRI review were based on chronic disease risk.
Chronic disease risk was considered for Adequate Intakes (AIs) and Acceptable Macronutrient Distribution Ranges (AMDRs).

Conclusions:

While chronic disease endpoints are increasingly considered, their direct application to RDAs remains limited.
Challenges persist in effectively utilizing chronic disease data for establishing comprehensive DRIs.