Related Experiment Video
Updated: Jul 3, 2026

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device
Published on: February 2, 2024
Permeate channel geometry to get constant separation efficiency in asymmetrical Flow Field-Flow fractionation cell
1Institut Européen des Membranes, Université Montpellier 2 (ENSCM, UM2, CNRS), CC047, 2 Place Eugène Bataillon, F-34095 Montpellier Cedex 5, France. philippe.dejardin@iemm.univ-montp2.fr
Abstract:
We consider an asymmetric Flow Field-Flow fractionation cell with a specific permeate channel geometry associated with an exponential variation of the channel breadth b=b(0)exp(-sz). The hydraulic characteristic length of the membrane is constant and linked to other characteristics of the cell. We determine the dependence of permeate channel height with distance to entrance to get both mean sample channel and membrane velocities constant, hence a constant efficiency of the separation process over the whole length of the cell.
Related Concept Videos
Steady, Laminar Flow Between Parallel Plates
Uniform Depth Channel Flow: Problem Solving
Uniform Depth Channel Flow
Column Efficiency: Rate Theory
During elution, a solute molecule experiences numerous transitions between stationary and mobile phases, exhibiting irregular residence times in...
Couette Flow
Steady, Laminar Flow in Circular Tubes

