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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
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Published on: September 11, 2013

Wilms' tumour: a complex enigma to decipher.

María José Robles-Frías1, Michele Biscuola, María Angeles Castilla

  • 1Pathology Department, HH.UU Virgen del Rocío, Sevilla, Spain. mariaj.robles.exts@juntadeandalucia.es

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 1, 2008
PubMed
Summary

Wilms' tumour (WT), a common childhood cancer, involves complex molecular pathways. Research links specific genetic changes to WT subtypes and outcomes, aiding prognosis and personalized treatment strategies.

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Area of Science:

  • Pediatric Oncology
  • Cancer Genetics
  • Molecular Biology

Background:

  • Wilms' tumour (WT) is the most frequent solid tumour in children.
  • The molecular mechanisms underlying WT development and progression are intricate, involving multiple genes and loci.
  • Understanding these pathways is crucial for improving patient outcomes.

Purpose of the Study:

  • To review recent findings on WT histology and molecular alterations.
  • To explore the relationship between molecular changes, histological types, and clinical outcomes.
  • To identify potential biomarkers for prognosis and targeted therapies.

Main Methods:

  • Literature review of recent research on Wilms' tumour.
  • Compilation of data on histological classifications.
  • Analysis of molecular alterations and their association with clinical data.

Main Results:

  • Specific molecular alterations are associated with distinct WT histological subtypes.
  • These molecular changes correlate with particular clinical outcomes.
  • Identification of potential prognostic markers for WT.

Conclusions:

  • Molecular alterations play a significant role in WT genesis, development, and behaviour.
  • Prognostic stratification and personalized treatment for WT can be enhanced by understanding molecular profiles.
  • Targeted therapies based on molecular subgroups may improve outcomes for high-risk WT patients.